Cyclic AMP turnover and signal amplification

آدنوزین منوفسفات حلقوی ( Cyclic AMP )

Cyclic AMP does not inhibit collagen-induced platelet signal transduction.

The adhesion of platelets to collagen and their activation is the primary event in haemostasis. Following adhesion, platelet aggregation mediated by ADP, thromboxane A2 and thrombin leads to the formation of a platelet plug. It is known that platelet activation by each of these agonists involves an increase in the cytosolic free Ca2+ concentration, and this has been thought to be controlled by ...

The Epidermis and Cyclic Amp

A hormone induces a rapid and profound change in the metabolic balance of its target organ. Early studies emphasized the extraordinarily low concentrations in which many hormones are effective. The fact that catechoiamines and polypeptides are frequently unable to penetrate the surface of cells made this seem all the more remarkable. The mechanism of their action, which for many years remained ...

The cyclic AMP pathway.

Cyclic adenosine 3′,5′-monophosphate (cAMP) was the first second messenger to be identified and plays fundamental roles in cellular responses to many hormones and neurotransmitters (Sutherland and Rall 1958). The intracellular levels of cAMP are regulated by the balance between the activities of two enzymes (see Fig. 1): adenylyl cyclase (AC) and cyclic nucleotide phosphodiesterase (PDE). Diffe...

Cyclic AMP signalling.

Cyclic adenosine 3′,5′-monophosphate (cAMP) was the first identified second messenger. A large number of studies during the past 30 years have elucidated the fundamental role of cAMP in the cellular response to many hormones and neurotransmitters. Although the main components in the cAMP-mediated signalling pathway are well known, recently new important players have been identified, which have ...